2,3,4,5,6,7-Hexahydro-1H-1-benzazonine-2,7-dione → 7-Hydroxy-1,3,4,5,6,7-hexahydro-2H-1-benzazonin-2-one

HRID 2417843노트

반응식

HRID 2417843 반응식
[NH:1]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[C:7](=[O:14])[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=[O:15].[BH4-].[Na+]>C(O)C>[OH:14][CH:7]1[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH:1][C:2](=[O:15])[CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

4

반응물 2

HCID 5775412,3,4,5,6,7-Hexahydro-1H-1-benzazonine-2,7-dioneHCID 4311764Sodium borohydride

생성물 1

HCID 133387277-Hydroxy-1,3,4,5,6,7-hexahydro-2H-1-benzazonin-2-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 3,4,5,6-tetrahydro-1H-(1)benzazonin-2,7-dione (14.2 g), J. Am. Chem. Soc. 88, 1049 (1966), and sodium borohydride (1.4 g) in ethanol (720 ml) is stirred at room temperature for 18 hours. The ethanol is removed under reduced pressure, and the residue dissolved in dichloromethane (350 ml). The solution is extracted with 2N hydrochloric acid (2×200 ml) and saturated brine (100 ml), and dried over sodium sulfate. The solvent is removed under reduced pressure to give 7-hydroxy-1,3,4,5,6,7-hexahydro-1-benzazonin-2-one.

후처리

  1. customThe ethanol is removed under reduced pressure
  2. dissolutionthe residue dissolved in dichloromethane (350 ml)
  3. extractionThe solution is extracted with 2N hydrochloric acid (2×200 ml) and saturated brine (100 ml)
  4. dry with materialdried over sodium sulfate
  5. customThe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-595276d433bc49f1991e7bc3ffc12a5f
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04470988

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