Acetic Anhydride → 4-Acetamidophenyl 4-O-(alpha-D-glucopyranosyl)-1-thio-beta-D-glucopyranoside

HRID 2417865노트

반응식

HRID 2417865 반응식
[C@H:1]1([O:12][C@@H:13]2[C@@H:26]([CH2:27][OH:28])[O:25][C@@H:16]([S:17][C:18]3[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=3)[C@H:15]([OH:29])[C@H:14]2[OH:30])[O:9][C@H:8]([CH2:10][OH:11])[C@@H:6]([OH:7])[C@H:4]([OH:5])[C@H:2]1[OH:3].[C:31](OC(=O)C)(=[O:33])[CH3:32]>O>[C@H:1]1([O:12][C@@H:13]2[C@@H:26]([CH2:27][OH:28])[O:25][C@@H:16]([S:17][C:18]3[CH:19]=[CH:20][C:21]([NH:24][C:31](=[O:33])[CH3:32])=[CH:22][CH:23]=3)[C@H:15]([OH:29])[C@H:14]2[OH:30])[O:9][C@H:8]([CH2:10][OH:11])[C@@H:6]([OH:7])[C@H:4]([OH:5])[C@H:2]1[OH:3]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 542687654-aminophenyl 4-O-(alpha-D-glucopyranosyl)-1-thio-beta-D-glucopyranoside

생성물 1

HCID 545032914-Acetamidophenyl 4-O-(alpha-D-glucopyranosyl)-1-thio-beta-D-glucopyranoside

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A 1.0 g portion of 4-aminophenyl 4-O-(α-D-glucopyranosyl)-1-thio-β-D-glucopyranoside was dissolved in 5 ml of water and 0.340 ml of acetic anhydride was added with vigorous stirring. After stirring 10 minutes the reaction was concentrated, reconcentrated from toluene, dissolved in ethanol and precipitated with ether, giving 836 mg of the desired intermediate.

후처리

  1. concentrationwas concentrated
  2. dissolutiondissolved in ethanol
  3. customprecipitated with ether

출처 및 근거

ORD 기록
ord-e85e80f0027a42138dfdf20e37984306
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04470976

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