Hydrogen Bromide → 4-(3-Bromopropyl)phenol

HRID 2417990노트

반응식

HRID 2417990 반응식
[BrH:1].O[CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1>O>[Br:1][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 824523-(4-Hydroxyphenyl)propanol

생성물 1

HCID 148170364-(3-Bromopropyl)phenol수율 84%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 48% hydrobromic acid solution (110 g) was added 4-(3-hydroxypropyl)phenol (25 g) and heated on a steam bath for 3 hours. After cooling, water (500 ml) was added, the oil was extracted with ether, washed with water and then with dilute sodium bicarbonate solution. The etheral extract was dried over potassium carbonate, evaporated and the residue was distilled in a Kugelrohr apparatus giving 29.6 g (84%) of 4-(3-bromopropyl)phenol, bp 180° (2 mm). The product was 92.6% pure by gas chromatography and mass spectrum was compatible with 4-(3-bromopropyl)phenol.

후처리

  1. temperatureheated on a steam bath for 3 hours
  2. temperatureAfter cooling
  3. extractionthe oil was extracted with ether
  4. washwashed with water
  5. extractionThe etheral extract
  6. dry with materialwas dried over potassium carbonate
  7. customevaporated
  8. distillationthe residue was distilled in a Kugelrohr apparatus

출처 및 근거

ORD 기록
ord-7a4a9b68a7b04eec8c287a132d269c07
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04471116

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