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Sodium Hydroxide → 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-[2-[4-[4-(1-methylethyl)aminobutyl]phenoxy]ethyl]piperazine trihydrochloride

HRID 2418012
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HRID 2418012 반응식
[Cl:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]([CH2:16][CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][N:22]([CH2:25][CH2:26]Cl)[CH2:21][CH2:20]3)[C:4]=2[CH:3]=1.[CH3:28][CH:29]([NH:31][CH2:32][CH2:33][CH2:34][CH2:35][C:36]1[CH:41]=[CH:40][C:39]([OH:42])=[CH:38][CH:37]=1)[CH3:30].[OH-].[Na+]>O>[ClH:1].[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]([CH2:16][CH2:17][CH2:18][N:19]3[CH2:20][CH2:21][N:22]([CH2:25][CH2:26][O:42][C:39]4[CH:40]=[CH:41][C:36]([CH2:35][CH2:34][CH2:33][CH2:32][NH:31][CH:29]([CH3:28])[CH3:30])=[CH:37][CH:38]=4)[CH2:23][CH2:24]3)[C:4]=2[CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 52754552-Chloro-10-[3-[4-(2-chloroethyl)piperazin-1-yl]propyl]phenothiazineHCID 20446958HCID 20446958, 화합물

생성물 1

HCID 133384751-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-[2-[4-[4-(1-methylethyl)aminobutyl]phenoxy]ethyl]piperazine trihydrochloride수율 127.4%

시약·촉매·용매 1

HCID 962
Water
용매

실험 절차

A solution of 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-(2-chloroethyl)piperazine (10 g) and 4-[4-(1-methylethyl)aminobutyl]phenol (4.9 g) was stirred at 55° under nitrogen and a solution of sodium hydroxide (0.94 g) in water (7 ml) was added. The reaction was stirred and heated at 55°-65° for 5 hours. The usual work-up yielded the crude trihydrochloride salt. Crystallization of the product from methanol-ethanol yielded 5.3 g of 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-[2-[4-[4-(1-methylethyl)aminobutyl]phenoxy]ethyl]piperazine trihydrochloride, mp 245°-248°.

후처리

  1. temperatureheated at 55°-65° for 5 hours
  2. customThe usual work-up yielded the crude trihydrochloride salt
  3. customCrystallization of the product from methanol-ethanol

출처 및 근거

ORD 기록
ord-4d7a565a87c84608b6d852583cb8a031
출처 데이터셋
uspto-grants-1984_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04471116

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