(4-bromo-2,6-dichlorophenyl)hydrazine → HCID 13118709, 화합물

HRID 2418122노트

반응식

HRID 2418122 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][NH2:11].C(O[CH:15]=[C:16]([C:23]#[N:24])[C:17]([O:19][CH2:20][CH:21]=[CH2:22])=[O:18])C>C(O)CCC>[NH2:24][C:23]1[N:10]([C:3]2[C:2]([Cl:1])=[CH:7][C:6]([Br:8])=[CH:5][C:4]=2[Cl:9])[N:11]=[CH:15][C:16]=1[C:17]([O:19][CH2:20][CH:21]=[CH2:22])=[O:18]

참가 물질

4

반응물 2

HCID 3816096(4-bromo-2,6-dichlorophenyl)hydrazineHCID 543446152-Propen-1-yl 2-cyano-3-ethoxy-2-propenoate

생성물 1

HCID 13118709HCID 13118709, 화합물

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

20.5 parts by weight of 2,6-dichloro-4-bromophenylhydrazine and 14.5 parts by weight of allyl ethoxymethylene-2-cyanoacetate in 100 parts by volume of n-butanol were refluxed for 4 hours. The butanol was evaporated off, the oily residue was dissolved in 150 parts by volume of ether, and dry halogen chloride gas was passed in, with ice-cooling. The hydrochloride which had precipitated was stirred with saturated sodium bicarbonate solution, and the precipitate was filtered off with suction and dried under reduced pressure to give 24.8 parts by weight of allyl 5-amino-1-(2,6-dichloro-4-bromophenyl)-pyrazole-4-carboxylate of melting point 85° C. (active ingredient No.6).

후처리

  1. customThe butanol was evaporated off
  2. dissolutionthe oily residue was dissolved in 150 parts by volume of ether, and dry halogen chloride gas
  3. temperaturecooling
  4. customThe hydrochloride which had precipitated
  5. filtrationthe precipitate was filtered off with suction
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-8633e0185b894ba7a562047f7edce1d6
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04472192

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