Methanol → 2,3-methylenedioxy-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carboxylic acid

HRID 2419015

반응식

HRID 2419015 반응식
[NH2:1][C:2]1[CH:11]=[C:10]2[O:12][CH2:13][O:14][C:9]2=[CH:8][C:3]=1[C:4]([O:6]C)=O.Cl[C:16]1[N:24]=[CH:23][CH:22]=[CH:21][C:17]=1[C:18]([OH:20])=[O:19].CO>CN(C=O)C>[CH2:13]1[O:12][C:10]2[CH:11]=[C:2]3[C:3]([C:4](=[O:6])[N:24]4[CH:23]=[CH:22][CH:21]=[C:17]([C:18]([OH:20])=[O:19])[C:16]4=[N:1]3)=[CH:8][C:9]=2[O:14]1

참가 물질

5

반응물 3

HCID 887MethanolHCID 762582-Chloronicotinic acidHCID 290838Methyl 6-amino-1,3-benzodioxole-5-carboxylate

생성물 1

HCID 203168392,3-methylenedioxy-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carboxylic acid

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2.00g (10.4 mmol) of methyl 2-amino-4,5-methylenedioxybenzoate, 1.67g (10.4 mmol) of 2-chloronicotinic acid and 50mg of KI was heated at 170° for 1 hour. The fusion or melt gradually solidified to an orange cake. The solid material was heated in boiling methanol (250 ml) and then filtered to yield 1.60g of crude product, mp. 273°-280° dec. The analytical sample was obtained by recrystallization from DMF, mp. 300°-304° dec.

후처리

  1. temperaturewas heated at 170° for 1 hour
  2. temperatureThe solid material was heated
  3. filtrationfiltered
  4. customto yield 1.60g of crude product, mp. 273°-280° dec

출처 및 근거

ORD 기록
ord-6c4ebe5621724a688721fa60eaf7865f
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04104389

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