Bromine → HCID 20315597, 화합물

HRID 2419359노트

반응식

HRID 2419359 반응식
[Br:1]Br.[C:3]([C:6]1[CH:21]=[CH:20][C:9]([O:10][CH2:11][C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[O:13])=[CH:8][CH:7]=1)(=[O:5])[CH3:4]>C(Cl)(Cl)Cl>[Br:1][CH2:4][C:3]([C:6]1[CH:21]=[CH:20][C:9]([O:10][CH2:11][C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[O:13])=[CH:8][CH:7]=1)=[O:5]

참가 물질

4

반응물 2

HCID 24408BromineHCID 34762Acetophenone, 4'-morpholinocarbonylmethoxy-

생성물 1

HCID 20315597HCID 20315597, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

A solution of bromine (8.0g.) in chloroform (30ml.) was added dropwise to a stirred solution of 4-(4-acetylphenoxyacetyl)morpholine (13.15g.) in chloroform (120ml.) at 35° C. After 1 hour, the reaction mixture was filtered and the filtrate was washed with water (2 × 30ml.), dried and evaporated. The residue was recrystallised from methanol/ether to give 4-[4-(bromoacetyl)phenoxyacetyl]morpholine, m.p. 105°-107° C.

후처리

  1. filtrationthe reaction mixture was filtered
  2. washthe filtrate was washed with water (2 × 30ml.)
  3. customdried
  4. customevaporated
  5. customThe residue was recrystallised from methanol/ether

출처 및 근거

ORD 기록
ord-85740456960642d68192ad4be19c2414
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04105790

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