Boron trifluoride etherate → 3-(Tetrahydropyran-2-ylthio)-2-methylpropanoic acid
반응식
[SH:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5].[O:8]1[CH:13]=[CH:12][CH2:11][CH2:10][CH2:9]1.B(F)(F)F.CCOCC.C(=O)([O-])[O-].[K+].[K+]>C1C=CC=CC=1>[O:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[S:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5]참가 물질
6
실험 절차
To a solution of 3-mercapto-2-methylpropanoic acid (2.4 g.) and freshly distillled 2,3-dihydro-4H-pyrane (1.9 g.) in benzene (60 ml.), boron trifluoride etherate (2.8 g.) is added. After two hours, potassium carbonate (4 g.) is added, the mixture is stirred and filtered. The filtrate is concentrated to dryness to yield 3-(tetrahydropyran-2-ylthio)-2-methylpropanoic acid.
후처리
- filtrationfiltered
- concentrationThe filtrate is concentrated to dryness
출처 및 근거
- ORD 기록
- ord-cf192b03bd9847c788456f18f38cb8e9
- 출처 데이터셋
- uspto-grants-1978_08
- 특허 번호
- US04105776
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