Benzylamine → HCID 178512100, 화합물

HRID 2419779노트

반응식

HRID 2419779 반응식
I.[Cl:2][C:3]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:4]=1[CH:5]=[N:6][NH:7][C:8](=[NH:11])SC.[CH2:17]([NH2:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[CH2:17]([NH:24][C:8]([NH:7][N:6]=[CH:5][C:4]1[C:12]([Cl:16])=[CH:13][CH:14]=[CH:15][C:3]=1[Cl:2])=[NH:11])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 178504060Methyl 3-(2,6-dichlorobenzylidene)thiocarbazimidate hydroiodide

생성물 1

HCID 178512100HCID 178512100, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 11.7 g. of methyl 3-(2,6-dichlorobenzylidene)thiocarbazimidate hydroiodide (U.S. Pat. No. 3,657,337) and 3.37 g. of benzylamine in 25 ml. of ethanol is heated at reflux for 18 hours and then evaporated to dryness under reduced pressure. The residue is partitioned between 80 ml. of diethyl ether and 100 ml. of water and the aqueous extract is made alkaline with ammonia. A pale yellow solid is recovered by filtration and recrystallized from aqueous ethanol, giving the desired product as colorless crystals, m.p. 133°-135° C.

후처리

  1. temperatureat reflux for 18 hours
  2. customevaporated to dryness under reduced pressure
  3. customThe residue is partitioned between 80 ml
  4. extractionof water and the aqueous extract
  5. filtrationA pale yellow solid is recovered by filtration
  6. customrecrystallized from aqueous ethanol

출처 및 근거

ORD 기록
ord-1407a14b899c4749a1a15926ffc3de7e
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04107326

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