Hydrochloric Acid → 1-(2,6-Difluorophenyl)methanamine--hydrogen chloride (1/1)
반응식
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]#[N:5].[ClH:11].[H][H]>O.C(O)C>[ClH:11].[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH2:4][NH2:5]참가 물질
6
실험 절차
A mixture of 5.00 g. of 2,6-difluorobenzonitrile and 1.0 g. of 50% water-wet 5% palladium on carbon catalyst in 100 ml. of concentrated HCl and 100 ml. of absolute ethanol is shaken at room temperature under 20 lbs. pressure of hydrogen for 48 hours. The mixture is filtered and the filtrate is diluted with 500 ml. of diethyl ether and allowed to stand. Filtration gives the desired product as colorless crystals, m.p. 197°-200° C.
후처리
- additionA mixture of 5.00 g
- filtrationThe mixture is filtered
- additionthe filtrate is diluted with 500 ml
- filtrationFiltration
출처 및 근거
- ORD 기록
- ord-86ecba610cd448b1be5df9d91fb236ae
- 출처 데이터셋
- uspto-grants-1978_08
- 특허 번호
- US04107326
반응 노트
불러오는 중…