3-Methoxybenzylamine → 4-Chloromethyl-N-(3-methoxybenzyl)benzamide

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][NH2:7].[Cl:11][CH2:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](Cl)=[O:18])=[CH:15][CH:14]=1>>[Cl:11][CH2:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([NH:7][CH2:6][C:5]2[CH:8]=[CH:9][CH:10]=[C:3]([O:2][CH3:1])[CH:4]=2)=[O:18])=[CH:15][CH:14]=1

참가 물질

반응물 2

HCID 211563-Methoxybenzylamine

HCID 701364-(Chloromethyl)benzoyl chloride

생성물 1

HCID 196900864-Chloromethyl-N-(3-methoxybenzyl)benzamide수율 83.9%

실험 절차

Using 3-methoxybenzylamine (754 mg, 5.39 mmol) and 4-chloromethylbenzoyl chloride (1.17 g, 6.0 mmol), the procedure of Reference Example 13 was repeated to obtain 1.31 g (83.9%) of the title compound in the form of colorless crystals.

출처 및 근거

ORD 기록: ord-fc00450aae7f43bba3081ae919487779
출처 데이터셋: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05728835

반응 노트

불러오는 중…