Hydrochloric Acid → 1-[3-(4-Chlorophenyl)-1,2-oxazol-5-yl]methanamine

HRID 2420122노트

반응식

HRID 2420122 반응식
[Br-].[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:13]=[C:12]([CH2:14][N+:15]34CN5CN(CN(C5)C3)C4)[O:11][N:10]=2)=[CH:5][CH:4]=1.Cl>CO>[NH2:15][CH2:14][C:12]1[O:11][N:10]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([Cl:2])=[CH:4][CH:5]=2)[CH:13]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 20339738HCID 20339738, 화합물

생성물 1

HCID 27641631-[3-(4-Chlorophenyl)-1,2-oxazol-5-yl]methanamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A 205 g. portion of the product of Example 5 was dissolved in 1.5 l. of methanol and 250 ml. of concentrated hydrochloric acid was added. The mixture was stirred at reflux temperature overnight, and the solvent was then evaporated under vacuum. The residue was neutralized with aqueous sodium hydroxide and the product was extracted from the aqueous mixture with methylene dichloride and was purified by evaporating the solvent and recrystallizing the residue from ethanol-petroleum ether. The product was 78 g. of 5-aminomethyl-3-(4-chlorophenyl)isoxazole, m.p. 81°.

후처리

  1. temperatureat reflux temperature overnight
  2. customthe solvent was then evaporated under vacuum
  3. extractionthe product was extracted from the aqueous mixture with methylene dichloride
  4. customwas purified
  5. customby evaporating the solvent
  6. customrecrystallizing the residue from ethanol-petroleum ether

출처 및 근거

ORD 기록
ord-bc52914786b947368ba3dfea748f34e5
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04109002

반응 노트

불러오는 중…