Hydrochloric Acid → 2-Carboxy-3-methyl-5,6-dihydro-1,4-dithiin

HRID 2420127

반응식

HRID 2420127 반응식
C([O:3][C:4]([C:6]1[S:11][CH2:10][CH2:9][S:8][C:7]=1[CH3:12])=[O:5])C.[OH-].[K+].Cl>CO>[C:4]([C:6]1[S:11][CH2:10][CH2:9][S:8][C:7]=1[CH3:12])([OH:5])=[O:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 12368330Ethyl 3-methyl-5,6-dihydro-1,4-dithiine-2-carboxylate

생성물 1

HCID 6005022-Carboxy-3-methyl-5,6-dihydro-1,4-dithiin

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3-Ethoxycarbonyl-2-methyl-5,6-dihydro-1,4-dithiin (10.0 g.) is heated at reflux for eight hours in a solution of potassium hydroxide (85%; 3.60 g.) in methanol (40 ml.). The cool solution is acidified wth 10% aqueous hydrochloric acid and the precipitate is removed by filtration and dried (8.1 g.). The crude product is recrystallized from ethanol to afford 2-carboxy-3-methyl-5,6-dihydro-1,4-dithiin, m.p. 179°-180° C., dec.

후처리

  1. customthe precipitate is removed by filtration
  2. customdried (8.1 g.)
  3. customThe crude product is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-70e4d169155a4e7c915561bf3de09c9b
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04109006

연결된 노트

불러오는 중…