Sodium Hydroxide → Clazolimine
반응식
[OH-:1].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]#[N:12])=[CH:6][CH:5]=1.[CH3:13][NH:14][C:15](=O)[CH2:16]Cl>O>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:16][C:15](=[O:1])[N:14]([CH3:13])[C:11]2=[NH:12])=[CH:6][CH:5]=1참가 물질
5
실험 절차
In 25 ml. of water containing 0.84 g. of sodium hydroxide was dissolved in 3.2 g. of p-chlorophenylcyanamide. To the clear solution was added 2.25 g. of N-methylchloroacetamide. The reaction mixture was stirred for 48 hours at room temperature. The precipitate was filtered to yield 1.9 g. of product, m.p. 182°-184° C. After the initial product was filtered, the filtrate was left stirring another three days. An additional 1.2 g. of product precipitated from solution. Total yield of product was 3.1 g. (66%).
후처리
- additionTo the clear solution was added 2.25 g
- filtrationThe precipitate was filtered
- customto yield 1.9 g
- filtrationAfter the initial product was filtered
- waitthe filtrate was left
- stirringstirring another three days
- customof product precipitated from solution
출처 및 근거
- ORD 기록
- ord-5fa5e1d65f7c4b00bf98fc3955064a78
- 출처 데이터셋
- uspto-grants-1978_08
- 특허 번호
- US04110445
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