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N-(3-chloropropyl)piperidine hydrochloride → HCID 20312089, 화합물

HRID 2420531
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HRID 2420531 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[NH:14][C:13](=[O:15])[NH:12][C:11]2=[O:16])=[CH:2]1.[Na].Cl.Cl[CH2:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>CN(C=O)C.C(O)C>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[NH:14][C:13](=[O:15])[N:12]([CH2:20][CH2:21][CH2:22][N:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[C:11]2=[O:16])=[CH:2]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 79624N-(3-chloropropyl)piperidine hydrochlorideHCID 5360545SodiumHCID 20186934HCID 20186934, 화합물

생성물 1

HCID 20312089HCID 20312089, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6228Dimethylformamide용매

실험 절차

5-(Indol-3-yl)hydantoin (8.6 g, 0.04 mole) in 200 ml of DMF was added to a solution of sodium (1.84 g, 0.08 mole) in 150 ml of anhydrous C2H5OH. N-(3-Chloropropyl)piperidine hydrochloride (7.9 g, 0.04 mole) was added and the mixture was heated to reflux with stirring for 18 hours, filtered and concentrated in vacuo to dryness. The concentrate was crystallized from aqueous methanol and twice recrystallized from aqueous DMF, yield 1.7 g, mp 233°-4° C.

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo to dryness
  5. customThe concentrate was crystallized from aqueous methanol
  6. customtwice recrystallized from aqueous DMF, yield 1.7 g, mp 233°-4° C.

출처 및 근거

ORD 기록
ord-a5442f0c0a3f40baa5db9b7c939d6cec
출처 데이터셋
uspto-grants-1978_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04110536

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