Hydrochloric Acid → 3-(4'-Fluoro-4-biphenylyl)butylamine, hydrochloride

반응식

C1(=O)[N:5]([CH2:6][CH2:7][CH:8]([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH3:9])C(=O)C2=CC=CC=C12.[ClH:29]>>[ClH:29].[F:22][C:19]1[CH:18]=[CH:17][C:16]([C:13]2[CH:14]=[CH:15][C:10]([CH:8]([CH3:9])[CH2:7][CH2:6][NH2:5])=[CH:11][CH:12]=2)=[CH:21][CH:20]=1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 203019791-Phthalimido-3-(4'-fluoro-4-biphenylyl)butane

생성물 1

HCID 203027163-(4'-Fluoro-4-biphenylyl)butylamine, hydrochloride

실험 절차

37.3 g of 1-phthalimido-3-(4'-fluoro-4-biphenylyl)- butane are boiled for 6 hours with 400 ml of 20% aqueous hydrochloric acid, evaporated and worked up using sodium hydroxide solution and ether to give 3-(4'-fluoro-4-biphenylyl)-butylamine, hydrochloride, m.p. 222°- 224°.

후처리

customevaporated

출처 및 근거

ORD 기록: ord-e61bfa65a8fd4139914cf8530f04c97b
출처 데이터셋: uspto-grants-1978_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04110447

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