Sodium borohydride → (6-Fluoro-3-pentylchroman-7-yl)methanol

HRID 2420647노트

반응식

HRID 2420647 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH:12]=[O:13])[O:8][CH2:7][CH:6]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:5]2.[BH4-].[Na+]>C(O)C.O>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH2:12][OH:13])[O:8][CH2:7][CH:6]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:5]2

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 592883516-Fluoro-3-pentylchroman-7-carbaldehyde

생성물 1

HCID 59288346(6-Fluoro-3-pentylchroman-7-yl)methanol

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

11.1 g (44.3 mmol) of 6-fluoro-3-pentylchroman-7-carbaldehyde are dissolved in 100 ml of ethanol, and 2.0 g (52.8 mmol) of sodium borohydride are added in portions. After 3 h, the batch is diluted with water and extracted three times with MTB ether. The combined org. phases are washed with sat. sodium chloride soln. and dried over sodium sulfate, the solvent is removed in vacuo, and the residue is filtered through silica gel with dichloromethane (Rf=0.3), giving (6-fluoro-3-pentylchroman-7-yl)methanol as a colourless solid.

후처리

  1. extractionextracted three times with MTB ether
  2. washphases are washed with sat. sodium chloride soln
  3. dry with materialand dried over sodium sulfate
  4. customthe solvent is removed in vacuo
  5. filtrationthe residue is filtered through silica gel with dichloromethane (Rf=0.3)

출처 및 근거

ORD 기록
ord-576e7ebc033046578a1287017d8be0aa
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07955664B2

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