Hydrochloric Acid → 12-Aminododecanoic acid amide hydrochloride

반응식

C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19](=[O:21])[NH2:20])(C)(C)C.[ClH:23]>>[ClH:23].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([NH2:20])=[O:21]

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 21103219(11-Carbamoylundecyl)carbamic acid tert-butyl ester

생성물 1

HCID 8663423712-Aminododecanoic acid amide hydrochloride

실험 절차

[(11-Carbamoylundecyl)carbamic acid tert-butyl ester (7) (0.085 g, 0.27 mmol) was treated with HCl (4 M in dioxane, 2 mL, 8 mmol) at room temperature for 14 hours. The reaction mixture was concentrated in vacuo and further dried under high vacuum. The white solid (0.068 g, 99%) was used directly without further purification: m/z (ESI) 215 [C12H26N2O+H]+.

후처리

concentrationThe reaction mixture was concentrated in vacuo
customfurther dried under high vacuum
customThe white solid (0.068 g, 99%) was used directly without further purification

출처 및 근거

ORD 기록: ord-90c188506b9f43b9985ee6ead1b629bc
출처 데이터셋: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07956059B2

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