Sodium Hydroxide → 1-(6-Chloropyrimidin-4-yl)azetidin-3-ol

HRID 242240노트

반응식

HRID 242240 반응식
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.Cl.[OH:10][CH:11]1[CH2:14][NH:13][CH2:12]1.[OH-].[Na+]>O>[Cl:8][C:6]1[N:7]=[CH:2][N:3]=[C:4]([N:13]2[CH2:14][CH:11]([OH:10])[CH2:12]2)[CH:5]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 775312,4-Dichloropyrimidine2회HCID 27592903-Hydroxyazetidine hydrochloride

생성물 1

HCID 579250791-(6-Chloropyrimidin-4-yl)azetidin-3-ol수율 115.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

7.2 g (48.7 mmol) 2,4-dichloropyrimidine are initially introduced into 140 ml water. 5.3 g (48.7 mmol) 3-hydroxyazetidine hydrochloride and 48.7 ml 1 N sodium hydroxide solution are added and the mixture is heated at 90° C. for 72 h (the 2,4-dichloropyrimidine being detectably volatile and precipitating in crystalline form on the condenser). The solvent is removed in vacuo and the residue is dried to give 10.4 g of the crude product, which is reacted without further purification.

후처리

  1. customprecipitating in crystalline form on the condenser)
  2. customThe solvent is removed in vacuo
  3. customthe residue is dried

출처 및 근거

ORD 기록
ord-ddae72d83b7742eca25dab5b5dbcefdf
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653111B2

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