Hydrazine hydrate (1:1) → 2-Hydrazinyl-5-Methylpyridine

HRID 242249

반응식

HRID 242249 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=1.O.[NH2:10][NH2:11]>C(OCCO)C>[NH:10]([C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=1)[NH2:11]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 5813932-Chloro-5-methyl-pyridine

생성물 1

HCID 41533962-Hydrazinyl-5-Methylpyridine

시약·촉매·용매 1

HCID 8076Glycol monoethyl ether용매

실험 절차

1.0 g (7.8 mmol) 2-chloro-5-methylpyridine are stirred under reflux in 5.7 ml (5.9 g, 117.6 mmol) hydrazine hydrate for 12 h. 10 ml ethylene glycol monoethyl ether are added to the cooled reaction mixture and the solvent is then removed completely on a rotary evaporator. This working step is repeated twice, methylene chloride is then added to the residue, the precipitate is filtered off, the filtrate is concentrated in vacuo and the residue is dried in vacuo.

후처리

  1. customthe solvent is then removed completely on a rotary evaporator
  2. additionmethylene chloride is then added to the residue
  3. filtrationthe precipitate is filtered off
  4. concentrationthe filtrate is concentrated in vacuo
  5. customthe residue is dried in vacuo

출처 및 근거

ORD 기록
ord-09437959471c43c8a62ecda9e00c3d66
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653111B2

연결된 노트

불러오는 중…