Pyridine → HCID 59774860, 화합물

HRID 2422528노트

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HRID 2422528 반응식
[CH:1]([C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:8][C:9]([C:13]#[N:14])=[N:10]2)=[CH:5][CH:4]=1)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[N:40]1C=CC=CC=1.[N:46](C(OC(C)C)=O)=[N:47]C(OC(C)C)=O>C1(C)C=CC=CC=1.[Zn](N=[N+]=[N-])N=[N+]=[N-]>[N:40]([CH2:1][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:8][C:9]([C:13]#[N:14])=[N:10]2)=[CH:5][CH:4]=1)=[N+:46]=[N-:47]

참가 물질

7

반응물 4

HCID 1049PyridineHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 574378457-Formyl-4-phenylquinoline-2-carbonitrile

생성물 1

HCID 59774860HCID 59774860, 화합물

시약·촉매·용매 2

HCID 178514646Zinc azide촉매HCID 1140Toluene용매

실험 절차

To a solution of 7-formyl-4-phenylquinoline-2-carbonitrile (520 mg, 2.0 mmol) in toluene (12 mL) was added triphenylphosphine (1.05 g, 4.0 mmol), Zn(N3)2.2 pyridine (461 mg, 1.5 mmol) and diisopropyl azodicarboxylate (787 μL, 4.0 mmol). The mixture was stirred at room temperature for 3 h, concentrated and purified on silica gel (eluting with EtOAc/hexanes, 3:7) to give the title compound. MS (+ESI): 286 (M+H)+.

후처리

  1. concentrationconcentrated
  2. custompurified on silica gel (eluting with EtOAc/hexanes, 3:7)

출처 및 근거

ORD 기록
ord-72e34ae5440f4cb79bb8595cbda265bb
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960409B2

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