Imidazole → ethyl 2-(1H-imidazol-1-yl)acetate

HRID 242258노트

반응식

HRID 242258 반응식
[Na].[NH:2]1[CH:6]=[CH:5][N:4]=[CH:3]1.Br[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C(O)C>[CH2:12]([O:11][C:9](=[O:10])[CH2:8][N:2]1[CH:6]=[CH:5][N:4]=[CH:3]1)[CH3:13]

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 7748Ethyl bromoacetateHCID 5360545Sodium

생성물 1

HCID 3798501ethyl 2-(1H-imidazol-1-yl)acetate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

118.2 g (5.1 mol) sodium are slowly added to 2.5 liters ethanol. 350.0 g (5.1 mol) imidazole are then added and 570 ml (858.6 g, 5.1 mol) ethyl bromoacetate are added dropwise at an internal temperature of 20-25° C. The mixture is stirred at RT for 24 h. The solid which has precipitated out is filtered off, the ethanol is removed in vacuo and the mixture is filtered again. The residue is purified by column chromatography over silica gel (mobile phase: ethyl acetate).

후처리

  1. customThe solid which has precipitated out
  2. filtrationis filtered off
  3. customthe ethanol is removed in vacuo
  4. filtrationthe mixture is filtered again
  5. customThe residue is purified by column chromatography over silica gel (mobile phase: ethyl acetate)

출처 및 근거

ORD 기록
ord-18f996ed93524ea7b83dd37ad0a09225
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653111B2

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