Ethyl 4-(3-naphthalen-2-yl-acryloylamino)benzoate → Methyl 4-(3-phenylacryloylamino)benzoate

HRID 2422937노트

반응식

HRID 2422937 반응식
[CH:1]1[C:10]2[C:5](=CC=CC=2)[CH:4]=[CH:3][C:2]=1[CH:11]=[CH:12][C:13]([NH:15][C:16]1[CH:26]=[CH:25][C:19]([C:20]([O:22][CH2:23]C)=[O:21])=[CH:18][CH:17]=1)=[O:14]>Cl>[C:2]1([CH:11]=[CH:12][C:13]([NH:15][C:16]2[CH:17]=[CH:18][C:19]([C:20]([O:22][CH3:23])=[O:21])=[CH:25][CH:26]=2)=[O:14])[CH:1]=[CH:10][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 1

HCID 67243223Ethyl 4-(3-naphthalen-2-yl-acryloylamino)benzoate

생성물 1

HCID 675852Methyl 4-(3-phenylacryloylamino)benzoate

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

This was obtained as a white solid from cinnamoyl chloride (1.1 g, 6.62 mmol) and ethyl 4-aminobenzoate (1.10 g, 6.62 mmol) in a similar manner as described for preparation of 42. The reaction mixture was stirred at room temperature overnight and the mixture was poured in HCl (aq, 2N, 20 ml). The product was extracted with DCM (2×20 ml), dried over Na2SO4 and the solvent removed under reduced pressure. The crude amide 41 was used in the next step without further purification.

후처리

  1. extractionThe product was extracted with DCM (2×20 ml)
  2. dry with materialdried over Na2SO4
  3. customthe solvent removed under reduced pressure
  4. customThe crude amide 41 was used in the next step without further purification

출처 및 근거

ORD 기록
ord-4f825ae8d3534a5bba9a7c942e720f98
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960434B2

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