Acetic Anhydride → 6-(2-Ethylaminophenyl)-5,6,7,8-tetrahydronaphthalen-2-ol

HRID 2423686노트

반응식

HRID 2423686 반응식
COC1C=C2C(=CC=1)CC(C1C=CC=CC=1N)CC2.C(OC(=O)C)(=O)C.[OH:27][C:28]1[CH:29]=[C:30]2[C:35](=[CH:36][CH:37]=1)[CH2:34][CH:33]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=1[NH:44][C:45](=O)[CH3:46])[CH2:32][CH2:31]2>N1C=CC=CC=1>[CH2:45]([NH:44][C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][C:38]=1[CH:33]1[CH2:32][CH2:31][C:30]2[CH:29]=[C:28]([OH:27])[CH:37]=[CH:36][C:35]=2[CH2:34]1)[CH3:46]

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 230875022-(6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamineHCID 66626221N-[2-(6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]acetamide

생성물 1

HCID 230874696-(2-Ethylaminophenyl)-5,6,7,8-tetrahydronaphthalen-2-ol

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A mixture of 2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamine (3.7 g), acetic anhydride (19 ml) and pyridine (19 ml) was stirred for 1 hour at room temperature. The reaction solution was concentrated in vacuo, then ethyl acetate (20 ml) and chloroform (5 ml) were added thereto, the crystal that was precipitated was filtered and dried. Synthesized from the total amount of the resulting N-[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]acetamide according to an analogous synthetic method to Example 364 described below, the total amount of N-[2-(6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]acetamide was used according to an analogous synthetic method to Example 337 described below to provide the title compound (2.3 g).

후처리

  1. concentrationThe reaction solution was concentrated in vacuo
  2. additionethyl acetate (20 ml) and chloroform (5 ml) were added
  3. customthe crystal that was precipitated
  4. filtrationwas filtered
  5. customdried
  6. customSynthesized from the total amount of the resulting N-[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]acetamide according to an analogous synthetic method to Example 364

출처 및 근거

ORD 기록
ord-af2284dc97444f8bb1e8ed9aaf4baf44
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960412B2

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