Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4,5-Trifluorobenzoyl chloride → (S)-3-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-4-methyl-5,6,7,8-tetrahydropyrazolo[4,3-b]azepine-1(4H)-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4,5-Trifluorobenzoyl chloride | HCID 145164 | — |
| 반응물 | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| 반응물 | 3,4-Difluorobenzoyl chloride | HCID 2724519 | — |
| 반응물 | tert-Butyl 3-oxoazepane-1-carboxylate | HCID 22831870 | — |
| 반응물 | (S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide | HCID 46863441 | — |
| 생성물 | (S)-3-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-4-methyl-5,6,7,8-tetrahydropyrazolo[4,3-b]azepine-1(4H)-carboxamide | HCID 59345359 | — |
반응 단계
Compound 69 was prepared according to the procedure described above for the synthesis of compound 37 except that 1-Boc-4-piperidone was replaced with tert-butyl 3-oxoazepane-1-carboxylate and 2,4,5-trifluorobenzoyl-chloride was replaced with 3,4-difluorobenzoylchloride. LCMS (+ESI) m/z=434.2 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08653127B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-40bdf287a2a14cebb12d18199dcae4fe |
| 출처 메모 | uspto-grants-2014_02 |