(R)-beta-aminophenethyl alcohol → (R)-N-(2-hydroxy-1-phenylethyl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide
반응식
C[C:2]([CH3:31])([CH3:30])[C@H:3]([NH:8][C:9]([N:11]1[C:19]2[CH2:18][CH2:17][N:16]([CH3:20])[CH2:15][C:14]=2[C:13]([C:21]2[CH:26]=[C:25]([F:27])[C:24]([F:28])=[CH:23][C:22]=2[F:29])=[N:12]1)=[O:10])[C:4](NC)=[O:5].N[C@H:33]([C:36]1C=CC=CC=1)[CH2:34]O>>[OH:5][CH2:4][C@H:3]([NH:8][C:9]([N:11]1[C:19]2[CH2:18][CH2:17][N:16]([CH3:20])[CH2:15][C:14]=2[C:13]([C:21]2[CH:26]=[C:25]([F:27])[C:24]([F:28])=[CH:23][C:22]=2[F:29])=[N:12]1)=[O:10])[C:2]1[CH:30]=[CH:36][CH:33]=[CH:34][CH:31]=1참가 물질
3
반응물 2
생성물 1
실험 절차
Compound 70 was prepared according to the procedure described for the synthesis of compound 37 by replacing tert-leucine methylamide with (R)-2-amino-2-phenylethanol. LCMS (+ESI) m/z=431.2 [M+H]+.