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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 242490생성일: 2026년 10월 26일

4-Chloro-2-fluorobenzoyl chloride → HCID 46830662, 화합물

https://huagongshe.com/reaction/242490

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참여 물질

역할이름HCID투입량
반응물4-Chloro-2-fluorobenzoyl chlorideHCID 2773601—
반응물(S)-N-(1-(2-hydroxyethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-3-(3,4-difluorophenyl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamideHCID 46220523—
생성물HCID 46830662HCID 46830662—

반응 단계

Compound 88 was prepared according to the procedure for the synthesis of compound 36 by replacing 3,4-difluorobenzoyl chloride with 4-chloro-2-fluorobenzoyl chloride. LCMS (+ESI) m/z=453.3 [M+H]+. 1H NMR (CDCl3) δ 7.90 (d, J=9.0 Hz, 1H), 7.67 (t, J=8.1 Hz, 1H), 7.16-7.24 (m, 2H), 6.45 (br, 1H), 4.65 (s, 2H), 4.18 (d, J=9.1 Hz, 1H), 3.94 (t, J=5.6 Hz, 2H), 3.73 (br, 2H), 3.45 (br, 2H), 3.17 (br, 2H), 1.10 (s, 9H). Purity: 98%.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08653127B2
출처 데이터셋uspto-grants-2014_02
ORD IDord-75fab7fabb924f75a9aa15e9a1f6b178
출처 메모uspto-grants-2014_02