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HRID242490

反应详情

EQUATION

反应方程式

HRID 242490 的结构方程式

REACTANTS

反应物

2
结构：O=C(Cl)c1ccc(Cl)cc1F
HCID2773601

4-Chloro-2-fluorobenzoyl chloride

C7H3Cl2FO

结构：CC(C)(C)[C@H](NC(=O)n1nc(-c2ccc(F)c(F)c2)c2c1CCOC2)C(=O)NCCO
HCID46220523

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)[C@H](NC(=O)n1nc(-c2ccc(Cl)cc2F)c2c1CCOC2)C(=O)NCCO
HCID46830662

未命名化合物

PROCEDURE

实验过程

Compound 88 was prepared according to the procedure for the synthesis of compound 36 by replacing 3,4-difluorobenzoyl chloride with 4-chloro-2-fluorobenzoyl chloride. LCMS (+ESI) m/z=453.3 [M+H]+. 1H NMR (CDCl3) δ 7.90 (d, J=9.0 Hz, 1H), 7.67 (t, J=8.1 Hz, 1H), 7.16-7.24 (m, 2H), 6.45 (br, 1H), 4.65 (s, 2H), 4.18 (d, J=9.1 Hz, 1H), 3.94 (t, J=5.6 Hz, 2H), 3.73 (br, 2H), 3.45 (br, 2H), 3.17 (br, 2H), 1.10 (s, 9H). Purity: 98%.