Bromine → HCID 67246500, 화합물

HRID 2425316노트

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HRID 2425316 반응식
[CH2:1]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])[CH2:13][CH2:12]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[Br:19]Br>C(Cl)(Cl)Cl>[Br:19][CH:13]1[CH2:12][C:11]2[C:15](=[CH:16][CH:17]=[C:9]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH:10]=2)[C:14]1=[O:18]

참가 물질

4

반응물 2

HCID 24408BromineHCID 67248522HCID 67248522, 화합물

생성물 1

HCID 67246500HCID 67246500, 화합물수율 84%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a solution of 2 (1.094 g, 4.48 mmol) in CHCl3 (10 mL) at 40° C. was added Br2 (0.23 mL, 4.477 mmol) dropwise over 15 minutes. The reaction was left to stir for 30 minutes. The resulting solution was concentrated and purified with silica gel chromatography eluding with hexanes-EtOAc (9:1). The reaction provided 3 (1.212 g, 3.75 mmol, 84%) as an orange liquid.

후처리

  1. waitThe reaction was left
  2. concentrationThe resulting solution was concentrated
  3. custompurified with silica gel chromatography

출처 및 근거

ORD 기록
ord-36f6bae739ec4cc2847bb8c17991aae6
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07964649B2

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