Iodoethane → 4-(1,1-Dimethylethyl)-2-ethoxy-1-iodobenzene

HRID 2425578노트

반응식

HRID 2425578 반응식
[C:1]([C:5]1[CH:6]=[CH:7][C:8]([I:12])=[C:9]([OH:11])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:19](I)[CH3:20]>C(O)C.C(OCC)C>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([I:12])=[C:9]([O:11][CH2:19][CH3:20])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

6

반응물 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 117478025-tert-Butyl-2-iodophenol

생성물 1

HCID 672460864-(1,1-Dimethylethyl)-2-ethoxy-1-iodobenzene수율 99%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 3283Diethyl Ether용매

실험 절차

The mixture of 5-tert-butyl-2-iodo-phenol (132.7 g, 480.6 mmol), potassium carbonate (265.7 g, 1923 mmol) and ethyl iodide (76.9 mL, 961.3 mmol) in ethanol (1.125 mL) was heated at reflux overnight. Upon cooling to room temperature, the reaction mixture was diluted with diethyl ether. The white solids were filtered off, and the filtrate was concentrated in vacuo to give 4-tert-butyl-2-ethoxy-1-iodo-benzene (144.7 g) as pale yellow oil.

후처리

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. filtrationThe white solids were filtered off
  4. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-73f996cd49394a1ba2d7b43b916c9472
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07964724B2

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