2-Chloroanthracene → 2-Phenylanthracene

HRID 2425801노트

반응식

HRID 2425801 반응식
Cl[C:2]1[CH:15]=[CH:14][C:13]2[C:4](=[CH:5][C:6]3[C:11]([CH:12]=2)=[CH:10][CH:9]=[CH:8][CH:7]=3)[CH:3]=1.[C:16]1(B(O)O)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.P([O-])([O-])([O-])=O.[K+].[K+].[K+]>C1(P(C2CCCCC2)C2CCCCC2)CCCCC1.C1(C)C=CC=CC=1>[C:16]1([C:2]2[CH:15]=[CH:14][C:13]3[C:4](=[CH:5][C:6]4[C:11]([CH:12]=3)=[CH:10][CH:9]=[CH:8][CH:7]=4)[CH:3]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

6

반응물 3

HCID 283082-ChloroanthraceneHCID 62657Potassium Phosphate, TribasicHCID 66827Phenylboronic Acid

생성물 1

HCID 5197172-Phenylanthracene수율 83.6%

시약·촉매·용매 2

HCID 75806Tricyclohexylphosphine촉매HCID 1140Toluene용매2회

실험 절차

Into a flask, 5.00 g of 2-chloroanthracene, 4.3 g of phenylboronic acid, 538 mg of tris(dibenzylieneacetone)dipalladium(0), 494 mg of tricyclohexyl phosphine, 9.98 g of tripotassium phosphate, and 75 ml of toluene were put, and the solution was stirred at reflux temperature for 2 hours under argon atmosphere. After heating, 1.5 liter of toluene was added to the reaction liquid, the liquid was cooled to room temperature and then filtrated, and thus the filtrates were purified by silica gel column chromatography. The filtrates were concentrated in an evaporator, the concentrates were recrystallized in toluene, and thus 5.0 g of 2-phenylanthracene was obtained.

후처리

  1. temperatureat reflux temperature for 2 hours under argon atmosphere
  2. temperatureAfter heating
  3. filtrationfiltrated
  4. customthus the filtrates were purified by silica gel column chromatography
  5. concentrationThe filtrates were concentrated in an evaporator
  6. customthe concentrates were recrystallized in toluene

출처 및 근거

ORD 기록
ord-704b3e31ffae423b90613d7e1090f63d
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07964293B2

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