Sodium Chloride → 5-(2-Cyanobutanoyl)thiophene-2-carbohydrazide

HRID 2425941노트

반응식

HRID 2425941 반응식
[C:1]([CH:3]([CH2:15][CH3:16])[C:4]([C:6]1[S:10][C:9]([C:11](OC)=[O:12])=[CH:8][CH:7]=1)=[O:5])#[N:2].[OH-].[K+].O.[NH2:20][NH2:21].[Cl-].[Na+]>CO>[C:1]([CH:3]([CH2:15][CH3:16])[C:4]([C:6]1[S:10][C:9]([C:11]([NH:20][NH2:21])=[O:12])=[CH:8][CH:7]=1)=[O:5])#[N:2]

참가 물질

6

반응물 4

HCID 5234Sodium ChlorideHCID 14797Potassium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 67087195Methyl 5-(2-cyanobutanoyl)thiophene-2-carboxylate

생성물 1

HCID 670873785-(2-Cyanobutanoyl)thiophene-2-carbohydrazide

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

Methyl 5-(2-cyanobutyryl)thiophene-2-carboxylate (213 mg, 0.90 mmol) in methanol was stirred with 0.1 M potassium hydroxide in methanol (9.0 mL, 0.90 mmol) at room temperature for 10 minutes and then with hydrazine monohydrate (225 mg, 4.50 mg) at 80° C. for 6 hours. After addition of saturated aqueous sodium chloride, the reaction solution was extracted with ethyl acetate, dried over anhydrous magnesium sulfate and concentrated to give the crude desired product.

후처리

  1. extractionthe reaction solution was extracted with ethyl acetate
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9b5ebb64dfaa4e4ea0cc52ddc7ad69e1
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968542B2

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