Cyclobutanone → HCID 86594882, 화합물

HRID 2426707

반응식

HRID 2426707 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:9]2)=[C:4]([F:22])[CH:3]=1.[C:23]1(=O)[CH2:26][CH2:25][CH2:24]1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C>>[F:22][C:4]1[CH:3]=[C:2]([NH:1][CH:23]2[CH2:26][CH2:25][CH2:24]2)[CH:7]=[CH:6][C:5]=1[N:8]1[CH2:12][CH2:11][C@H:10]([CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:9]1

참가 물질

4

반응물 3

HCID 14496CyclobutanoneHCID 2724942TriacetoxyborohydrideHCID 68988249tert-Butyl (R)-[1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamate

생성물 1

HCID 86594882HCID 86594882, 화합물

실험 절차

tert-Butyl (R)-[1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamate was alkylated with cyclobutanone using triacetoxyborohydride as reducing agent by method N. This resulted in the product with the molecular weight of 363.48 (C20H30FN3O2); MS (ESI): 364 (M+H+).

후처리

  1. customThis resulted in the product with the molecular weight of 363.48 (C20H30FN3O2)

출처 및 근거

ORD 기록
ord-07e9dd52e18c463ab234649294923abb
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968550B2

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