4-Fluorobenzonitrile → 4-(4-Methyl-piperidin-1-yl)-benzonitrile
반응식
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[CH3:10][CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>C(OCC)(=O)C>[CH3:10][CH:11]1[CH2:16][CH2:15][N:14]([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=2)[CH2:13][CH2:12]1참가 물질
4
실험 절차
4-Fluorobenzonitrile (1.21 g) was heated with 4-methylpiperidine (1.00 g) at 180° C. for 1 hour. The mixture was then taken up in ethyl acetate, washed with water, 2N sodium hydroxide solution and saturated sodium bicarbonate solution, dried over sodium sulfate, concentrated and crystallized from n-pentane. This resulted in the product with the molecular weight of 200.29 (C13H16N2); MS (ESI): 201 (M+H+).
후처리
- washwashed with water, 2N sodium hydroxide solution and saturated sodium bicarbonate solution
- dry with materialdried over sodium sulfate
- concentrationconcentrated
- customcrystallized from n-pentane
- customThis resulted in the product with the molecular weight of 200.29 (C13H16N2)
출처 및 근거
- ORD 기록
- ord-edcd27d0fbb44ec981e70cf961a57362
- 출처 데이터셋
- uspto-grants-2011_06
- 특허 번호
- US07968550B2
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