Sodium borohydride → HCID 67251600, 화합물

HRID 2426761노트

반응식

HRID 2426761 반응식
[BH4-].[Na+].[CH3:3][C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12](=[O:14])[CH3:13])[CH:7]=[C:6]([CH3:15])[C:5]=1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][O:23][C:24]2[CH:31]=[CH:30][C:27]([CH:28]=[O:29])=[CH:26][CH:25]=2)[CH:17]=1>CO>[OH:29][CH2:28][C:27]1[CH:26]=[CH:25][C:24]([O:23][CH2:22][C:18]2[CH:17]=[C:16]([C:5]3[C:4]([CH3:3])=[CH:9][C:8]([O:10][CH2:11][CH:12]([OH:14])[CH3:13])=[CH:7][C:6]=3[CH3:15])[CH:21]=[CH:20][CH:19]=2)=[CH:31][CH:30]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 57787755HCID 57787755, 화합물

생성물 1

HCID 67251600HCID 67251600, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In an atmosphere of nitrogen, sodium borohydride was added to a methanol solution of 4-{[2′,6′-dimethyl-4′-(2-oxopropoxy)biphenyl-3-yl]methoxy}benzaldehyde under ice-cooling, followed by stirring at room temperature for 2 hours to obtain 1-[(-3′-{[4-(hydroxymethyl)phenoxy]methyl}-2,6-dimethylbiphenyl-4-yl)oxy]propan-2-ol. By adding chloroform and manganese dioxide to the resulting compound and stirring at 60° C. for 5 hours, 4-{[4′-(2-hydroxypropoxy)-2′,6′-dimethylbiphenyl-3-yl]methoxy}benzaldehyde was obtained.

후처리

  1. temperaturecooling

출처 및 근거

ORD 기록
ord-8e54e369a25345d08b118618c96ea4c3
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968552B2

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