Methylhydrazine → 1-Methyl-3-(trifluoromethyl)-1H-pyrazole

HRID 2427020

반응식

HRID 2427020 반응식
C(O[CH:4]=[CH:5][C:6](=O)[C:7]([F:10])([F:9])[F:8])C.[CH3:12][NH:13][NH2:14]>CO>[CH3:12][N:13]1[CH:4]=[CH:5][C:6]([C:7]([F:10])([F:9])[F:8])=[N:14]1

참가 물질

4

반응물 2

HCID 6061MethylhydrazineHCID 27803954-Ethoxy-1,1,1-trifluoro-3-buten-2-one

생성물 1

HCID 27804041-Methyl-3-(trifluoromethyl)-1H-pyrazole

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a mixture of 18 g of 4-ethoxy-1,1,1-trifluoro-3-butene-2-one and 50 ml of methanol was added 5.7 ml of methylhydrazine, and the mixture was heated to reflux for 4 hours. The reaction mixture was allowed to cool to room temperature, concentrated under reduced pressure, and subjected to distillation under reduced pressure (60° C./15 mmHg) to obtain 8.71 g of 1-methyl-3-trifluoromethyl-1H-pyrazole of the formula:

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 4 hours
  3. concentrationconcentrated under reduced pressure
  4. distillationsubjected to distillation under reduced pressure (60° C./15 mmHg)

출처 및 근거

ORD 기록
ord-87ab800a8452418e8d11e0a88bc6da28
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968573B2

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