Sodium Hydroxide → HCID 57949645, 화합물

HRID 2427495노트

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HRID 2427495 반응식
[Br:1][C:2]1[CH:9]=[C:8]([CH3:10])[C:5]([C:6]#[N:7])=[C:4]([O:11][CH3:12])[CH:3]=1.[OH-:13].[Na+]>CO>[Br:1][C:2]1[CH:9]=[C:8]([CH3:10])[C:5]([C:6]([NH2:7])=[O:13])=[C:4]([O:11][CH3:12])[CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 454803844-bromo-2-methoxy-6-methylbenzonitrile

생성물 1

HCID 57949645HCID 57949645, 화합물수율 90%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

4-Bromo-2-methoxy-6-methyl benzonitrile (7.3 g, 32.4 mmol) was stirred in MeOH (100 mL) and 5N NaOH (100 mL) at 100° C. for 12 hours. The reaction was cooled to room temperature and the methanol was removed under reduced pressure. The reaction mixture was extracted with CH2Cl2 and the solvent was removed under reduced pressure to yield the product (7.13 g, 90%). 1H NMR (300 MHz, CDCl3): δ 7.03 (d, 1H), 6.94 (d, 1H), 5.83 (br s, 2H), 3.85 (s, 3H), 2.39 (s, 3H).

후처리

  1. customthe methanol was removed under reduced pressure
  2. extractionThe reaction mixture was extracted with CH2Cl2
  3. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-d43eeb57947f49f49ffdc57d393ffec6
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968570B2

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