Benzoyl Peroxide → Methyl 4-bromo-2-(bromomethyl)-6-chlorobenzoate

HRID 2427645노트

반응식

HRID 2427645 반응식
[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:9]([CH3:10])=[CH:8][C:7]([Br:11])=[CH:6][C:5]=1[Cl:12].[Br:14]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:5]([Cl:12])=[CH:6][C:7]([Br:11])=[CH:8][C:9]=1[CH2:10][Br:14]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 45480505Methyl 4-bromo-2-chloro-6-methylbenzoate

생성물 1

HCID 59512234Methyl 4-bromo-2-(bromomethyl)-6-chlorobenzoate

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of 4-bromo-2-chloro-6-methyl-benzoic acid methyl ester (2.447 g, 9.27 mmol,), N-bromosuccinimide (1.815 g, 10.2 mmol), and benzoyl peroxide (0.051 g, 0.22 mmol) in carbon tetrachloride (30 mL) was refluxed until most of the starting materials were consumed (as analyzed by GC/MS). The resulting mixture was filtered and the filtrate concentrated to afford 4-bromo-2-bromomethyl-6-chloro-benzoic acid methyl ester. The product was used without further purification.

후처리

  1. temperaturewas refluxed until most of the starting materials
  2. customwere consumed (as analyzed by GC/MS)
  3. filtrationThe resulting mixture was filtered
  4. concentrationthe filtrate concentrated

출처 및 근거

ORD 기록
ord-3cfd6acd75324c6e98fe2e700e3d8aa4
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968570B2

반응 노트

불러오는 중…