Dichloromethane → Methyl 2,4-dichloro-6-methylbenzoate

HRID 2427749노트

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HRID 2427749 반응식
[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:9]([CH3:10])=[CH:8][C:7](Br)=[CH:6][C:5]=1[Cl:12].[Cl:14]CCl>CN(C=O)C.Cl[Cu]>[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:9]([CH3:10])=[CH:8][C:7]([Cl:14])=[CH:6][C:5]=1[Cl:12]

참가 물질

5

반응물 2

HCID 6344DichloromethaneHCID 45480505Methyl 4-bromo-2-chloro-6-methylbenzoate

생성물 1

HCID 57949430Methyl 2,4-dichloro-6-methylbenzoate수율 65%

시약·촉매·용매 2

HCID 62652Cuprous chloride촉매HCID 6228Dimethylformamide용매

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온도
140 °C

실험 절차

A solution of the 4-bromo-2-chloro-6-methyl-benzoic acid methyl ester (1.31 g, 5 mmol) in DMF was treated with CuCl (1.96 g, 20 mmol) and stirred at 140° C. for 1-2 h. After this time, the reaction mixture was diluted with dichloromethane (15 mL) and the solids removed by filtration. The filtrate was concentrated. Silica gel column chromatography using, typically 30% ethyl acetate in hexane, afforded 2,4-dichloro-6-methyl-benzoic acid methyl ester (0.72 g, 65%).

후처리

  1. customthe solids removed by filtration
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-718a85a4f2824feab158b3241790722b
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968570B2

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