Ethylene carbonate → 2-(2,6-Dichloro-4-methylphenoxy)ethan-1-ol

HRID 2428085

반응식

HRID 2428085 반응식
[Cl:1][C:2]1[C:7]([OH:8])=[C:6]([Cl:9])[CH:5]=[C:4]([CH3:10])[CH:3]=1.[O:11]1[CH2:15][CH2:14]OC1=O>N1C=CN=C1>[Cl:1][C:2]1[CH:3]=[C:4]([CH3:10])[CH:5]=[C:6]([Cl:9])[C:7]=1[O:8][CH2:14][CH2:15][OH:11]

참가 물질

4

반응물 2

HCID 7303Ethylene carbonateHCID 170772,6-Dichloro-4-methylphenol

생성물 1

HCID 213969022-(2,6-Dichloro-4-methylphenoxy)ethan-1-ol수율 75%

시약·촉매·용매 1

HCID 795Imidazole촉매

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온도
160 °C

실험 절차

In a three-necked flask equipped with a gas droplet counter and an efficient cooling system, a mixture of 2,6-dichloro-p-cresol (20.0 g, 113 mmol), [1,3]dioxolan-2-one (9.95 g, 113 mmol) and imidazole (115 mg, 1.70 mmol) was heated to 160° C. for 25 h. The mixture was allowed to cool to rt. Purification by FC (Et2O/heptane 1.1) yielded the title compound (18.7 g, 75%). LC-MS: tR=0.88 min.

후처리

  1. customIn a three-necked flask equipped with a gas droplet counter
  2. temperatureto cool to rt
  3. customPurification by FC (Et2O/heptane 1.1)

출처 및 근거

ORD 기록
ord-7c44d5c67c06435498534780c07c1f13
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07968720B2

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