Taurine → Sodium 2-(2-bromopropionylamino)-ethanesulfonate

HRID 24299

반응식

HRID 24299 반응식
[NH2:1][CH2:2][CH2:3][S:4]([OH:7])(=[O:6])=[O:5].[OH-].[Na+:9].[Br:10][CH:11]([CH3:15])[C:12](Br)=[O:13]>O.ClCCl>[Br:10][CH:11]([CH3:15])[C:12]([NH:1][CH2:2][CH2:3][S:4]([O-:7])(=[O:6])=[O:5])=[O:13].[Na+:9]

참가 물질

6

반응물 3

HCID 1123TaurineHCID 14798Sodium HydroxideHCID 79047Propanoyl bromide, 2-bromo-

생성물 1

HCID 23709737Sodium 2-(2-bromopropionylamino)-ethanesulfonate

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

25.6 g of taurine (204 mmol) and 16.38 g of NaOH (409 mmol) were dissolved in 20 ml of deionized water. 2-Bromopropionyl bromide (44 g, 21.36 ml, 204 mmol) dissolved in 50 ml of dichloromethane was then added to the solution drop wise at 0° C. over 30 minutes. During the addition, a large amount of solid was produced. The reaction flask was manually agitated to thoroughly mix the compounds until no more exotherm was observed with additional agitation. The reaction mixture was then allowed to sit for 1 hour. The solid was filtered and washed with a small amount of absolute ethanol and then ethyl ether and then dried in vacuo. The compound can be used in this state or recrystallized from methanol.

후처리

  1. additionwas then added to the solution drop wise at 0° C. over 30 minutes
  2. additionDuring the addition
  3. customa large amount of solid was produced
  4. additionto thoroughly mix the compounds until no more exotherm
  5. filtrationThe solid was filtered
  6. washwashed with a small amount of absolute ethanol
  7. dry with materialethyl ether and then dried in vacuo
  8. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-eb8d8b4b51e54713ba1babd8bd6e5d5f
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855840B2

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