Sodium Hydroxide → 6-Amino-1,3-dihydro-2H-indol-2-one

HRID 24345

반응식

HRID 24345 반응식
O.O.[Sn](Cl)(Cl)(Cl)Cl.[N+:8]([C:11]1[CH:16]=[C:15]([N+:17]([O-])=O)[CH:14]=[CH:13][C:12]=1[CH2:20][C:21]([OH:23])=O)([O-])=O.[OH-].[Na+]>C(O)C>[NH2:17][C:15]1[CH:16]=[C:11]2[C:12]([CH2:20][C:21](=[O:23])[NH:8]2)=[CH:13][CH:14]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 2215132,4-Dinitrophenylacetic acidHCID 85782573Tin tetrachloride dihydrate

생성물 1

HCID 5905386-Amino-1,3-dihydro-2H-indol-2-one수율 101.3%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
90 °C

실험 절차

Tin chloride dihydrate (225 g) was added to a solution of 2,4-dinitrophenylacetic acid (22.6 g) in ethanol (450 ml). The mixture was heated at 90° C. for 10 hours. The reaction mixture was cooled and adjusted to pH 11 with 12M sodium hydroxide. The solids were removed by filtration and the filtrate was concentrated. The residue was treated with ethanol (300 ml). Insoluble materials were removed by filtration and washed with ethanol (5×60 ml). The combined ethanol solutions were evaporated and the solid obtained was dried under vacuum to give 15 g of 6-amino-2-oxindole as a brown powder.

후처리

  1. temperatureThe reaction mixture was cooled
  2. customThe solids were removed by filtration
  3. concentrationthe filtrate was concentrated
  4. additionThe residue was treated with ethanol (300 ml)
  5. customInsoluble materials were removed by filtration
  6. washwashed with ethanol (5×60 ml)
  7. customThe combined ethanol solutions were evaporated
  8. customthe solid obtained
  9. customwas dried under vacuum

출처 및 근거

ORD 기록
ord-495d6f7339d542228f12d5bb89aa27ff
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855730B2

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