p-Cyanobenzyl alcohol → N-Hydroxy-4-(hydroxymethyl)benzimidamide

HRID 243821노트

반응식

HRID 243821 반응식
Cl.[NH2:2][OH:3].[OH:4][CH2:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1.C(=O)([O-])O.[Na+]>CO>[OH:3][N:2]=[C:10]([C:9]1[CH:12]=[CH:13][C:6]([CH2:5][OH:4])=[CH:7][CH:8]=1)[NH2:11]

참가 물질

5

반응물 3

HCID 160549p-Cyanobenzyl alcoholHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium Bicarbonate

생성물 1

HCID 53437716N-Hydroxy-4-(hydroxymethyl)benzimidamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of hydroxylamine hydrochloride (5.2 g), 4-(hydroxymethyl)benzonitrile (5.0 g), and sodium hydrogen carbonate (12.6 g) in methanol (50 mL) was heated to reflux for 20 hours. The reaction mixture was filtered through Celite (trade name). Thus, the filtrate was concentrated to thereby give the title compound having the following physical properties. The product was used for next reaction without further purification.

후처리

  1. temperatureto reflux for 20 hours
  2. filtrationThe reaction mixture was filtered through Celite (trade name)
  3. concentrationThus, the filtrate was concentrated

출처 및 근거

ORD 기록
ord-6fc5d554ea6a4ccb8735b339b659b6ee
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653305B2

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