5-Fluoro-2-iodobenzoic acid → 5-Iodo-2-[1,2,3]triazol-2-yl-benzoic acid

HRID 243828

반응식

HRID 243828 반응식
F[C:2]1[CH:3]=[CH:4][C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].FC1C=CC([I:26])=C(C=1)C(O)=O>>[I:26][C:2]1[CH:3]=[CH:4][C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

참가 물질

3

반응물 2

HCID 131585835-Fluoro-2-iodobenzoic acidHCID 670869485-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

생성물 1

HCID 670867325-Iodo-2-[1,2,3]triazol-2-yl-benzoic acid

실험 절차

The title compound was prepared in a manner analogous to Intermediate 1, substituting 2-bromo-5-iodobenzoic acid for 5-fluoro-2-iodo-benzoic acid in Step A. 1H NMR (400 MHz, CD3OD): 8.09 (d, J=2.0, 1H), 8.03-7.97 (m, 1H), 7.95-7.86 (m, 3H), 7.53 (d, J=8.4, 1H).

출처 및 근거

ORD 기록
ord-d9a258a52f604289a23b3b751f2da77e
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653263B2

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