2-Chloro-6-methylnicotinic acid → 5-[1,2,3]Triazol-2-yl-benzo[1,3]dioxole-4-carboxylic acid

반응식

[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)N=1.BrC1C=CC2[O:21][CH2:22][O:23]C=2C=1C(O)=O.ClC1N=C(C)C=CC=1C(O)=O>>[N:12]1[N:11]([C:4]2[CH:1]=[CH:2][C:10]3[O:21][CH2:22][O:23][C:9]=3[C:5]=2[C:6]([OH:8])=[O:7])[N:15]=[CH:14][CH:13]=1

참가 물질

반응물 3

HCID 1217242-Chloro-6-methylnicotinic acid

HCID 125141065-Bromobenzo(1,3)dioxole-4-carboxylic acid

HCID 670868556-Methyl-2-[1,2,3]triazol-2-yl-nicotinic acid

생성물 1

HCID 671162815-[1,2,3]Triazol-2-yl-benzo[1,3]dioxole-4-carboxylic acid

실험 절차

The title compound was prepared in a manner analogous to Intermediate 70 substituting 5-bromobenzo[1,3]dioxole-4-carboxylic acid for 2-chloro-6-methylnicotinic acid. MS (ESI): mass calculated for C10H7N3O4, 233.18; m/z found 234.3 [M+H]+. 1H NMR (400 MHz, CD3OD): 7.85 (s, 2H), 7.23 (d, J=8.4 Hz, 1H), 7.04 (d, J=8.4 Hz, 1H), 6.16 (s, 2H).

출처 및 근거

ORD 기록: ord-b341898934e34a8893c5ce2a657c19dc
출처 데이터셋: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08653263B2

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