Dimethylformamide → 2-Vinyloxyethyl phthalimide

HRID 244285

반응식

HRID 244285 반응식
[CH:1]([O:3][CH2:4][CH2:5]Cl)=[CH2:2].[C:7]1(=[O:17])[NH:11][C:10](=[O:12])[C:9]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:8]12.[K].CN(C=O)C>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.O>[CH:1]([O:3][CH2:4][CH2:5][C:16]1[CH:15]=[CH:14][CH:13]=[C:9]2[C:10]([NH:11][C:7](=[O:17])[C:8]=12)=[O:12])=[CH2:2]

참가 물질

6

반응물 3

HCID 6228DimethylformamideHCID 80742-Chloroethyl vinyl etherHCID 24194345Phthalimide potassium salt

생성물 1

HCID 219723452-Vinyloxyethyl phthalimide

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 962Water용매

실험 절차

2-Vinyloxy Ethyl Phthalimide was prepared via reacting 2-chloroethyl vinyl ether (25 g, 0.24 mol) and potassium phthalimide (25 g, 0.135 mol) in 100° C. DMF (75 ml) using tetra n-butyl ammonium bromide (0.5 g) as the phase transfer catalyst. This solution was heated for 6 h and then crashed out in water and filtered. This solid was then recrystallized twice from methanol to give white crystals.

후처리

  1. customin 100° C
  2. temperatureThis solution was heated for 6 h
  3. filtrationfiltered
  4. customThis solid was then recrystallized twice from methanol
  5. customto give white crystals

출처 및 근거

ORD 기록
ord-cf7bb9a4849140d2a6db19c0f84693ff
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658211B2

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