C([O:3][C:4]([C:6]1[N:7]([CH2:33][CH:34]=[CH2:35])[CH:8]=[C:9]([C:11]([C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[N:22]([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)[N:21]=[CH:20]3)([OH:16])[C:12]([F:15])([F:14])[F:13])[CH:10]=1)=[O:5])C.[Cl-].[NH4+]>CCO.[OH-].[Na+].O>[CH2:33]([N:7]1[CH:8]=[C:9]([C:11]([C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[N:22]([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)[N:21]=[CH:20]3)([OH:16])[C:12]([F:14])([F:15])[F:13])[CH:10]=[C:6]1[C:4]([OH:5])=[O:3])[CH:34]=[CH2:35]A mixture of 1-allyl-4-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]-1-hydroxyethyl}-1H-pyrrole-2-carboxylic acid ethyl ester (728 mg, 1.5 mmol) in 5 mL of EtOH and 30 mL of 3 M NaOH was stirred at room temperature. After 18 hours, the mixture was neutralized with saturated aqueous ammonium chloride, diluted with water, and extracted with EtOAc. The combined organic layers were dried, filtered, and concentrated in vacuo to provide 660 mg (96%) of the title compound as a beige solid. MS m/z 460.25 (MH+).
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