Pyridine → N-(4-fluorophenyl)acetamide

HRID 244466

반응식

HRID 244466 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:15](Cl)(=[O:17])[CH3:16]>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:15](=[O:17])[CH3:16])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 97314-Fluoroaniline

생성물 1

HCID 9601N-(4-fluorophenyl)acetamide수율 91.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a chilled (ice-bath) solution of 4-fluorophenylamine (2.9 mL, 30 mmol) and anhydrous pyridine (3.7 mL, 45 mmol) in methylene chloride (50 mL) was slowly added a solution of acetyl chloride (2.4 mL, 33 mmol) in methylene chloride (10 mL). After 15 minutes, the mixture was concentrated in vacuo and the residue was diluted with cold water. The resulting precipitate was filtered, washed with water and dried to afford 4.2 g of N-(4-fluorophenyl)acetamide as an off white solid. MS m/z 154 (MH+).

후처리

  1. concentrationthe mixture was concentrated in vacuo
  2. additionthe residue was diluted with cold water
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-e2199747741544279ac642f150d5786b
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658637B2

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