Hydrochloric Acid → 3-(3-{2,2,2-Trifluoro-1-[1-(4-fluorophenyl)-1H-benzotriazol-5-yl]-1-hydroxyethyl}indol-1-yl)propane-1,2-diol
반응식
Cl.CC1(C)[O:7][CH:6]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([C:18]([C:24]3[CH:39]=[CH:38][C:27]4[N:28]([C:31]5[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=5)[N:29]=[N:30][C:26]=4[CH:25]=3)([OH:23])[C:19]([F:22])([F:21])[F:20])=[CH:10]2)[CH2:5][O:4]1>C(#N)C>[F:21][C:19]([F:20])([F:22])[C:18]([C:11]1[C:12]2[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:9]([CH2:8][CH:6]([OH:7])[CH2:5][OH:4])[CH:10]=1)([C:24]1[CH:39]=[CH:38][C:27]2[N:28]([C:31]3[CH:32]=[CH:33][C:34]([F:37])=[CH:35][CH:36]=3)[N:29]=[N:30][C:26]=2[CH:25]=1)[OH:23]참가 물질
4
반응물 2
생성물 1
시약·촉매·용매 1
실험 절차
At room temperature, approximately 200 μL of concentrated HCl was added to 1-[1-(2,2-dimethyl-1,3-dioxolan-4-ylmethyl)-1H-indol-3-yl]-2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-benzotriazol-5-yl]ethanol (100 mg) in aqueous acetonitrile. After 90 minutes, LCMS showed one peak MS m/z 501 (MH+) for the desired product. The mixture was then concentrated and the residue diluted with sodium bicarbonate and extracted with ethyl acetate. The combined organic extracts were washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo to afford 95 mg of the title compound as an off-white solid.