Sodium Hydroxide → N-[3-(dimethylamino)phenyl]methanesulphonamide
반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH3:6][N:7]([CH3:15])[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([NH2:14])[CH:9]=1.[OH-].[Na+]>O>[CH3:6][N:7]([CH3:15])[C:8]1[CH:9]=[C:10]([NH:14][S:2]([CH3:1])(=[O:4])=[O:3])[CH:11]=[CH:12][CH:13]=1참가 물질
5
실험 절차
Methanesulphonyl chloride (838 mg, 7.35 mmol) was added slowly to a cooled solution (5° C.) of N,N-dimethyl-1,3-phenylenediamine (1.00 g, 7.35 mmol) and sodium hydroxide (5M, 1.5 cm3) in water (10 cm3). The reaction was allowed to warm to room temperature overnight. The mixture was extracted with chloroform (3×15 cm3). The combined extracts were dried over sodium sulphate, filtered and the solvent removed under reduced pressure. Column chromatography (1:20 methanol/dichloromethane) gave the target material as a brown oil (1.24 g, 79%).
후처리
- extractionThe mixture was extracted with chloroform (3×15 cm3)
- dry with materialThe combined extracts were dried over sodium sulphate
- filtrationfiltered
- customthe solvent removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-b8fd1201b5654d798122c4747976812a
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08658665B2
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